The Most Cited & Most Disruptive Pouch Papers

The most-cited and most disruptive pouch papers, computed from the NIH Open Citation Collection across 12,473 curated articles. The disruption index (CD; Funk & Owen-Smith 2017) measures how strongly a paper eclipses the prior work it builds on rather than reinforcing it.

#	Paper	CD index	Citations
1	Surgical treatment of toxic megacolon. Ileostomy and colostomy to prepare patients for colectomy. Turnbull — American journal of surgery · 1971	+0.730	120
2	Three hundred cases of diffuse ulcerative colitis treated by total colectomy and ileo-rectal anastomosis. Aylett — British medical journal · 1966	+0.636	137
3	Intra-abdominal "reservoir" in patients with permanent ileostomy. Preliminary observations on a procedure resulting in fecal "continence" in five ileostomy patients. Kock — Archives of surgery (Chicago, Ill. : 1960) · 1969	+0.589	474
4	Laparoscopic total proctocolectomy with creation of ileostomy for ulcerative colitis: report of two cases. Peters — J Laparoendosc Surg · 1992	+0.496	63
5	Proctocolectomy without ileostomy for ulcerative colitis. Parks A — Br Med J · 1978	+0.400	1,023
6	Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis Burke — N Engl J Med · 2020	+0.371	53
7	Ulcerative colitis with relative sparing of the rectum. Clinical features, histology, and prognosis. Spiliadis — Diseases of the colon and rectum · 1987	+0.356	48
8	Ileostomy for ulcerative colitis; technique, complications, and management. WARREN — Surgery, gynecology & obstetrics · 1951	+0.314	136
9	Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease. Hellers — Gut · 1980	+0.292	362
10	Life expectancy after colectomy and ileorectal anastomosis for familial adenomatous polyposis. Nugent — Diseases of the colon and rectum · 1993	+0.270	145
11	Balloon dilatation of biliary strictures through a choledochojejuno-cutaneous fistula. Hutson — Annals of surgery · 1984	+0.241	89
12	Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program. Orlanski-Meyer — Gastroenterology · 2021	+0.218	46
13	Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy. Blackstone — Gastroenterology · 1981	+0.207	412
14	The relative significance of preoperative oral antibiotics, mechanical bowel preparation, and preoperative peritoneal contamination in the avoidance of sepsis after radical surgery for ulcerative colitis and Crohn's disease of the large bowel. Barker — The British journal of surgery · 1971	+0.205	57
15	Treatment of colorectal and ileoanal anastomotic sinuses Whitlow — Dis Colon Rectum · 1997	+0.166	55
16	Comparison of handsewn with stapled loop ileostomy closures Hull — Dis Colon Rectum · 1996	+0.161	58
17	Hyperalimentation as primary therapy for inflammatory bowel disease. Fischer — American journal of surgery · 1973	+0.154	153
18	Autosuture GIA gun: a new application in the treatment of hypopharyngeal diverticula. Martin-Hirsch — The Journal of laryngology and otology · 1993	+0.149	78
19	Course of ulcerative colitis: analysis of changes in disease activity over years. Langholz — Gastroenterology · 1994	+0.142	523
20	Repair of persistent perineal sinuses by means of a pedicle flap of musculus gracilis. Case report. Bartholdson — Scand J Plast Reconstr Surg · 1975	+0.135	41
21	Surgical measures as supplements to the management of idiopathic ulcerative colitis; cancer, cirrhosis, and arthritis as frequent complications. DENNIS — Surgery · 1952	+0.133	84
22	The treatment of acute toxic ulcerative colitis by ileostomy and simultaneous colectomy. CRILE — Gastroenterology · 1951	+0.130	50
23	Proctitis and colitis following diversion of the fecal stream. Glotzer — Gastroenterology · 1981	+0.126	239
24	Quality of life after prophylactic colectomy and ileorectal anastomosis in patients with familial adenomatous polyposis Church — Dis Colon Rectum · 1996	+0.124	53
25	Fate of the rectal mucosa after rectal mucosectomy and ileoanal anastomosis. Heppell — Dis Colon Rectum · 1983	+0.121	105
26	Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease Mortensen — Scand J Gastroenterol Suppl · 1996	+0.118	332
27	Portal bacteraemia in cases of ulcerative colitis submitted to colectomy. Eade — Lancet (London, England) · 1969	+0.118	90
28	An innovative technique for colorectal specimen retrieval: a new era of "natural orifice specimen extraction" (N.O.S.E) Palanivelu — Dis Colon Rectum · 2008	+0.117	112
29	Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Riddell — Human pathology · 1983	+0.113	1,579
30	Cyclosporine in severe ulcerative colitis refractory to steroid therapy. Lichtiger — The New England journal of medicine · 1994	+0.110	1,416
31	Serum antibodies to Bacteroides species in chronic inflammatory bowel disease. Tvede — Scandinavian journal of gastroenterology · 1983	+0.109	42
32	Thrombocytosis in chronic inflammatory bowel disease. Morowitz — Annals of internal medicine · 1968	+0.106	169
33	Choice of operation for the toxic megacolon phase of nonspecific ulcerative colitis. Turnbull — The Surgical clinics of North America · 1970	+0.106	42
34	Mortality in patients with familial adenomatous polyposis. Arvanitis — Diseases of the colon and rectum · 1990	+0.105	324
35	The fate of ileorectal anastomosis in Crohn's disease. Burman — Gut · 1971	+0.104	57
36	Subtotal colectomy for ulcerative colitis: complications related to the rectal remnant. Carter F — Dis Colon Rectum · 1991	+0.101	75
37	Yang needle tunneling technique in creating antireflux and continent mechanisms. — The Journal of urology · 1993	+0.100	138
38	Influence on sexual function of abdominoperineal resection for ulcerative colitis. STAHLGREN — The New England journal of medicine · 1958	+0.100	40
39	The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients. Greenstein — Medicine · 1976	+0.099	1,060
40	Social prognosis in patients with ulcerative colitis. Hendriksen — British medical journal · 1980	+0.097	51
41	Single-patient randomised clinical trial. Use in determining optimum treatment for patient with inflammation of Kock continent ileostomy reservoir McLeod — Lancet · 1986	+0.093	67
42	Endoscopic gastroduodenal polypectomy. — Annals of surgery · 1984	+0.092	65
43	Laparoscopically assisted ileocolectomy in Crohn's disease. Milsom — Surgical laparoscopy & endoscopy · 1993	+0.091	77
44	Quantitative method for measuring adjuvant-induced granuloma angiogenesis in insulin-treated diabetic mice. Kimura — Journal of pharmacobio-dynamics · 1986	+0.091	44
45	Nerve-sparing robot-assisted radical cystoprostatectomy and urinary diversion. — BJU international · 2003	+0.091	438
46	Aetiology of disruption of intestinal anastomoses. Irvin — The British journal of surgery · 1973	+0.088	326
47	Preliminary experience with laparoscopic intestinal surgery for Crohn's disease. Ludwig — American journal of surgery · 1996	+0.084	99
48	A repair operation for recurrent dislocation of peroneal tendons. Das De — J Bone Joint Surg Br · 1985	+0.082	59
49	Colpocystodefecography. Hock — Diseases of the colon and rectum · 1993	+0.081	78
50	Small bowel ischemia after Roux-en-Y gastric bypass complicated by pregnancy: a case report. — The American surgeon · 2005	+0.079	44
51	Laparoscopic surgery for inflammatory bowel disease Liu — Am Surg · 1995	+0.078	45
52	Unexplained bronchopulmonary disease with inflammatory bowel disease. Kraft — Archives of internal medicine · 1976	+0.073	200
53	Readmissions after colorectal surgery cannot be predicted. Azimuddin — Diseases of the colon and rectum · 2001	+0.072	77
54	Results of surgery for inflammatory bowel disease: a further survey of one hospital region. Ritchie — British medical journal · 1974	+0.069	53
55	Regression of rectal adenomas after colectomy and ileorectal anastomosis for familial adenomatous polyposis. Nicholls — British medical journal (Clinical research ed.) · 1988	+0.069	43
56	Effect of neostigmine on integrity of ileorectal anastomoses. Bell — British medical journal · 1968	+0.066	57
57	Epidemiological study of ulcerative proctocolitis in Indian migrants and the indigenous population of Leicestershire. Probert — Gut · 1992	+0.064	218
58	The fate of the rectal stump after subtotal colectomy for ulcerative colitis. Oakley — Diseases of the colon and rectum · 1985	+0.062	47
59	Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Rutgeerts — Lancet (London, England) · 1991	+0.060	594
60	Urinary diversion via a continent ileal reservoir: clinical results in 12 patients. Kock — The Journal of urology · 1982	+0.058	457
61	Clinical outcome of ulcerative colitis in children. Hyams — The Journal of pediatrics · 1996	+0.058	125
62	An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir Moskowitz — Int J Colorectal Dis · 1986	+0.058	299
63	Laparoscopic adjustable gastric banding. Belachew — World journal of surgery · 1998	+0.057	203
64	Safety of the temporary loop ileostomy Hallböök — Colorectal Dis · 2002	+0.056	62
65	PLACE OF A DOUBLE-BARRELLED ILEOSTOMY IN ULCERATIVE COLITIS AND CROHN'S DISEASE OF THE COLON: A PRELIMINARY REPORT. TRUELOVE — British medical journal · 1965	+0.056	66
66	Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Ng — 2017	+0.056	4,514
67	Adenocarcinoma of the ileostomy occurring after colectomy for ulcerative colitis: report of a case. Sigler — Diseases of the colon and rectum · 1969	+0.055	58
68	Quality of life after radical cystectomy for bladder cancer in patients with an ileal conduit, cutaneous or urethral kock pouch. — The Journal of urology · 1999	+0.053	149
69	Prospective study of the effect of resection of the rectum on male sexual function Fazio — World J Surg · 1980	+0.052	77
70	Laparoscopic total abdominal colectomy. A prospective trial Wexner — Dis Colon Rectum · 1992	+0.050	191
71	Let sleeping dogs lie: role of the omentum in the ileal pouch-anal anastomosis procedure Ambroze — Dis Colon Rectum · 1991	+0.050	40
72	Optum Labs: building a novel node in the learning health care system. Wallace Paul — Health Aff (Millwood) · 2014	+0.050	350
73	Surgery of the large bowel for emergent conditions. Staged vs primary resection. — Archives of surgery (Chicago, Ill. : 1960) · 1969	+0.048	44
74	Ileal pouch-anal anastomosis without temporary, diverting ileostomy Metcalf — Dis Colon Rectum · 1986	+0.047	54
75	Mucosal morphology, bacteriology, and absorption in intra-abdominal ileostomy reservoir. Philipson — Scand J Gastroenterol · 1975	+0.047	82
76	Long term prognosis in ulcerative colitis--based on results from a regional patient group from the county of Copenhagen. Hendriksen — Gut · 1985	+0.047	219
77	Portal hypertension and bleeding ileal varices after colectomy and ileostomy for chronic ulcerative colitis. Cameron — Gut · 1970	+0.046	49
78	Ulcerative colitis and colorectal cancer. A population-based study. Ekbom — The New England journal of medicine · 1990	+0.046	1,432
79	Results of the pelvic-pouch procedure in patients with Crohn's disease. Deutsch A — Dis Colon Rectum · 1991	+0.044	132
80	Laparoscopic total abdominal colectomy with ileorectal anastomosis for familial adenomatous polyposis. Milsom — Diseases of the colon and rectum · 1997	+0.043	53
81	Early complications following surgical treatment for Crohn's disease. Heimann — Annals of surgery · 1985	+0.042	77
82	Long-term complications and prognosis following major surgery for ulcerative colitis. Watts — The British journal of surgery · 1966	+0.041	181
83	Centralized registration, prophylactic examination, and treatment results in improved prognosis in familial adenomatous polyposis. Results from the Danish Polyposis Register. Bülow — Scandinavian journal of gastroenterology · 1995	+0.039	76
84	Probiotics, immunomodulation, and health benefits Gill — Adv Exp Med Biol · 2008	+0.039	123
85	Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'. Price — Journal of clinical pathology · 1978	+0.037	264
86	Prognosis after surgery for colonic Crohn's disease. Andrews H — Br J Surg · 1989	+0.036	54
87	Spontaneous resolution of rectal polyps in patients with familial polyposis following abdominal colectomy and ileorectal anastomosis. — Diseases of the colon and rectum · 1988	+0.036	58
88	Review article: short chain fatty acids in health and disease Cook — Aliment Pharmacol Ther · 1998	+0.034	396
89	Self-reported food intolerance in chronic inflammatory bowel disease. Ballegaard — Scandinavian journal of gastroenterology · 1997	+0.033	70
90	Relationship of backwash ileitis to ileal pouchitis after ileal pouch-anal anastomosis Gustavsson — Dis Colon Rectum · 1987	+0.033	71
91	Three years' experience with an ileal low pressure bladder substitute. — British journal of urology · 1989	+0.033	168
92	Comparison of bowel function after ileorectal anastomosis for ulcerative colitis and colonic polyposis. Newton — Gut · 1975	+0.033	62
93	Perineal sinus after removal of the rectum. Occlusion with fibrin adhesive. — American journal of surgery · 1983	+0.032	43
94	Proceedings: Intravenous hyperalimentation in the treatment of inflammatory diseases of the bowel. — Archives of surgery (Chicago, Ill. : 1960) · 1974	+0.032	89
95	Pouchitis associated with primary cytomegalovirus infection Moonka — Am J Gastroenterol · 1998	+0.030	67
96	Patient characteristics associated with venous thromboembolic events: a cohort study using pooled electronic health record data. Kaelber David — J Am Med Inform Assoc · 2012	+0.030	112
97	Changes in the bidirectional sodium flux across the intestinal mucosa in Crohn's disease. Allan — Gut · 1975	+0.030	47
98	Very low intraluminal colonic pH in patients with active ulcerative colitis. Fallingborg — Digestive diseases and sciences · 1993	+0.030	172
99	Long-term ileostomy complications in patients with ulcerative colitis and Crohn's disease. Carlstedt — Int J Colorectal Dis · 1987	+0.029	57
100	Tubulovillous adenomas in a continent ileostomy after proctocolectomy for familial polyposis Beart — Dig Dis Sci · 1982	+0.029	42

* Disruption index (CD) is unreliable for papers published within the last 5 years (insufficient forward-citation window); such papers are excluded from this ranking. CD ranges from +1 (fully disruptive) to -1 (fully consolidating).

#	Paper	CD index	Citations
1	Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Ng — 2017	+0.056	4,514
2	Ulcerative colitis. Ungaro — Lancet (London, England) · 2017	-0.004	2,722
3	Cancer treatment and survivorship statistics, 2022. Miller — CA: a cancer journal for clinicians · 2022	+0.006	2,200
4	British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Lamb — Gut · 2019	-0.006	1,751
5	Ulcerative colitis Ordás — Lancet · 2012	+0.009	1,662
6	Epidemiology and natural history of inflammatory bowel diseases. Cosnes — Gastroenterology · 2011	+0.014	1,625
7	The gut microbiota and host health: a new clinical frontier. Marchesi, Julian R — Gut · 2016	+0.000	1,583
8	Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Riddell — Human pathology · 1983	+0.113	1,579
9	Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. Giardiello — The New England journal of medicine · 1993	+0.005	1,456
10	Ulcerative colitis and colorectal cancer. A population-based study. Ekbom — The New England journal of medicine · 1990	+0.046	1,432
11	Cyclosporine in severe ulcerative colitis refractory to steroid therapy. Lichtiger — The New England journal of medicine · 1994	+0.110	1,416
12	Inflammatory bowel disease: clinical aspects and established and evolving therapies Baumgart — Lancet · 2007	+0.004	1,414
13	Microbial influences in inflammatory bowel diseases Sartor — Gastroenterology · 2008	-0.010	1,410
14	Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders Magro — J Crohns Colitis · 2017	-0.011	1,372
15	Ulcerative colitis Kobayashi — Nat Rev Dis Primers · 2020	-0.005	1,240
16	The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients. Greenstein — Medicine · 1976	+0.099	1,060
17	Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee Kornbluth — Am J Gastroenterol · 2010	-0.009	1,027
18	Ulcerative colitis. Le Berre Catherine — Lancet · 2023	-0.001	1,024
19	Proctocolectomy without ileostomy for ulcerative colitis. Parks A — Br Med J · 1978	+0.400	1,023
20	Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial Gionchetti — Gastroenterology · 2000	-0.069	1,016
21	Minimally invasive colon resection (laparoscopic colectomy). Jacobs — Surgical laparoscopy & endoscopy · 1991	—	973
22	Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Frøslie — Gastroenterology · 2007	+0.023	923
23	Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study. Järnerot — Gastroenterology · 2005	-0.059	821
24	Guidelines for the management of inflammatory bowel disease in adults. Carter — Gut · 2004	-0.003	786
25	Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Madsen — Gastroenterology · 2001	+0.000	761
26	Reduced Paneth cell alpha-defensins in ileal Crohn's disease Wehkamp — Proc Natl Acad Sci U S A · 2005	-0.018	761
27	Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Colombel — Gastroenterology · 2011	-0.031	752
28	Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics Sartor — Gastroenterology · 2004	-0.010	750
29	Recurrent CT, cumulative radiation exposure, and associated radiation-induced cancer risks from CT of adults. Sodickson — Radiology · 2009	-0.005	742
30	Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. Ferlazzo — The Journal of experimental medicine · 2002	-0.011	741
31	Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial Gionchetti — Gastroenterology · 2003	-0.067	740
32	Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management Dignass — J Crohns Colitis · 2012	-0.015	723
33	Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies. Jess — Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2012	-0.014	716
34	Effects of gender, body composition, and menopause on plasma concentrations of leptin. Rosenbaum — The Journal of clinical endocrinology and metabolism · 1996	-0.019	702
35	Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. D'Haens — Gastroenterology · 1998	+0.008	677
36	Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. Ménard — Journal of bacteriology · 1993	+0.000	652
37	Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy. Martin — Cell · 2019	-0.001	645
38	Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation Sinha — Cell Host Microbe · 2020	-0.002	618
39	Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Labayle — Gastroenterology · 1991	-0.002	615
40	Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches Sartor — Gastroenterology · 2017	-0.004	612
41	Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis Mimura — Gut · 2004	-0.046	608
42	European evidence based consensus for endoscopy in inflammatory bowel disease. Annese Vito — J Crohns Colitis · 2013	-0.010	598
43	Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Rutgeerts — Lancet (London, England) · 1991	+0.060	594
44	Predicting outcome in severe ulcerative colitis. Travis — Gut · 1996	-0.035	591
45	Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort (IBSEN Study). Solberg — Scandinavian journal of gastroenterology · 2009	-0.016	576
46	Pouchitis after ileal pouch-anal anastomosis: a Pouchitis Disease Activity Index Sandborn — Mayo Clin Proc · 1994	-0.006	572
47	Total colectomy, mucosal proctectomy, and ileoanal anastomosis. Utsunomiya — Dis Colon Rectum · 1980	-0.091	570
48	Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society. Winawer — Gastroenterology · 2006	-0.016	553
49	PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Loftus — Gut · 2005	-0.010	546
50	Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study Becker — J Am Coll Surg · 1996	+0.026	543
51	Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients Fazio — Ann Surg · 2013	-0.066	529
52	Course of ulcerative colitis: analysis of changes in disease activity over years. Langholz — Gastroenterology · 1994	+0.142	523
53	Response to corticosteroids in severe ulcerative colitis: a systematic review of the literature and a meta-regression. Turner — Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2007	-0.008	493
54	Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients. Kelly — The American journal of gastroenterology · 2014	-0.027	487
55	Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial. Laharie — Lancet (London, England) · 2012	-0.014	483
56	Visual motion processing and sensory-motor integration for smooth pursuit eye movements. — Annual review of neuroscience · 1987	-0.019	481
57	Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis. Rutter — Gastroenterology · 2006	-0.048	479
58	A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. Saxon — The Journal of allergy and clinical immunology · 1990	-0.001	478
59	Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee Kornbluth — Am J Gastroenterol · 2004	-0.006	477
60	Intra-abdominal "reservoir" in patients with permanent ileostomy. Preliminary observations on a procedure resulting in fecal "continence" in five ileostomy patients. Kock — Archives of surgery (Chicago, Ill. : 1960) · 1969	+0.589	474
61	Ulcerative Colitis in Adults: A Review. Gros — JAMA · 2023	-0.000	463
62	J ileal pouch-anal anastomosis for chronic ulcerative colitis: complications and long-term outcome in 1310 patients Meagher — Br J Surg · 1998	-0.034	460
63	Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Schmitz — Gastroenterology · 1999	+0.019	459
64	Urinary diversion via a continent ileal reservoir: clinical results in 12 patients. Kock — The Journal of urology · 1982	+0.058	457
65	Intensive intravenous regimen for severe attacks of ulcerative colitis. Truelove — Lancet (London, England) · 1974	-0.033	455
66	Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis? Bernstein — Lancet (London, England) · 1994	-0.067	450
67	Cancer risk and life expectancy of children with ulcerative colitis. Devroede — The New England journal of medicine · 1971	+0.023	447
68	Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis. Seow — Gut · 2010	-0.028	447
69	Impact of Clostridium difficile on inflammatory bowel disease. Issa — Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2007	+0.011	443
70	Nerve-sparing robot-assisted radical cystoprostatectomy and urinary diversion. — BJU international · 2003	+0.091	438
71	Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFα therapy: results from the COIN study. van der Valk — Gut · 2014	+0.019	436
72	Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003-2005: a population-based study from the Danish Crohn colitis database. Vind — The American journal of gastroenterology · 2006	-0.011	429
73	Declining risk of colorectal cancer in inflammatory bowel disease: an updated meta-analysis of population-based cohort studies. Lutgens — Inflammatory bowel diseases · 2013	-0.002	426
74	Consensus conference: Colorectal cancer screening and surveillance in inflammatory bowel disease. Itzkowitz — Inflammatory bowel diseases · 2005	-0.030	420
75	Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy. Blackstone — Gastroenterology · 1981	+0.207	412
76	Familial adenomatous polyposis. Galiatsatos Polymnia — Am J Gastroenterol · 2006	-0.005	412
77	Natural course of Crohn's disease after ileocolic resection: endoscopically visualised ileal ulcers preceding symptoms. Olaison — Gut · 1992	-0.062	410
78	Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response. Lloyd — Immunology today · 1992	+0.013	405
79	Familial adenomatous polyposis Half — Orphanet J Rare Dis · 2009	-0.002	402
80	Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis. Weismüller — Gastroenterology · 2017	-0.037	399
81	Review article: short chain fatty acids in health and disease Cook — Aliment Pharmacol Ther · 1998	+0.034	396
82	Colorectal cancer risk and mortality in patients with ulcerative colitis. Langholz — Gastroenterology · 1992	-0.018	394
83	Ileal pouch-anal anastomosis for chronic ulcerative colitis. Long-term results Pemberton — Ann Surg · 1987	-0.023	394
84	Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis. Ardizzone — Gut · 2006	-0.019	388
85	Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gillen — Gut · 1994	-0.019	387
86	Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Nugent K — Br J Surg · 1993	-0.056	387
87	Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis. Burak Kelly — Am J Gastroenterol · 2004	-0.036	382
88	Evidence-based clinical practice guidelines for inflammatory bowel disease Matsuoka — J Gastroenterol · 2018	-0.000	381
89	Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. Landy, Jonathan — World journal of gastroenterology · 2016	+0.000	379
90	C-reactive protein as a marker for inflammatory bowel disease. Vermeire — Inflammatory bowel diseases · 2004	+0.005	374
91	Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years. Lennard-Jones — Gut · 1990	-0.055	374
92	Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis Penna — Gut · 1996	-0.060	371
93	Greater risk of incisional hernia with morbidly obese than steroid-dependent patients and low recurrence with prefascial polypropylene mesh Sugerman — Am J Surg · 1996	-0.017	367
94	Factors affecting the outcome of endoscopic surveillance for cancer in ulcerative colitis. Connell — Gastroenterology · 1994	-0.079	364
95	Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease. Hellers — Gut · 1980	+0.292	362
96	Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition Turner — J Pediatr Gastroenterol Nutr · 2018	-0.005	362
97	Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 3: special situations Van Assche — J Crohns Colitis · 2013	-0.004	359
98	Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis. Brentnall — Gastroenterology · 1994	-0.006	359
99	Proctocolectomy with ileal reservoir and anal anastomosis Parks — Br J Surg · 1980	-0.044	359
100	Sulindac for polyposis of the colon. Waddell — American journal of surgery · 1989	-0.009	357

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