Top 100 Most Disruptive

The 100 most-disruptive papers by the Funk & Owen-Smith CD (disruption) index, which measures how much a paper redirected the field away from prior work.

Curated by · Professor of Surgery, Department of Colon & Rectal Surgery, Cleveland Clinic · Corpus last refreshed · Publications

Ranked from the ileal pouch-anal anastomosis (IPAA) and continent-ileostomy literature.

The disruption index is unreliable for papers published within the last 5 years. The forward-citation window is too short to score them, so recent papers are excluded from this ranking. A research reference for clinicians and trainees, not treatment advice.

#PaperAltmetricCD index
1Post-surgical pyoderma gangrenosum of the vaginal vault associated with ulcerative colitis and Behçet's disease; a case report.
Lilford · 1989 · Eur J Obstet Gynecol Reprod Biol
+0.960
24 cites
2Long-term survival between total colectomy versus proctocolectomy in patients with FAP: a registry-based, observational cohort study
Ardoino · 2020 · Tumori
+0.818
20 cites
3Ileostomy in pregnancy.
Hudson · 1972 · Proc R Soc Med
+0.737
36 cites
4Surgical treatment of toxic megacolon. Ileostomy and colostomy to prepare patients for colectomy.
Turnbull · 1971 · Am J Surg
+0.730
120 cites
5Total colectomy and ileorectal anastomosis in diffuse ulcerative colitis.
AYLETT · 1957 · Br Med J
+0.703
34 cites
6Three hundred cases of diffuse ulcerative colitis treated by total colectomy and ileo-rectal anastomosis.
Aylett · 1966 · Br Med J
+0.636
137 cites
7Intra-abdominal "reservoir" in patients with permanent ileostomy. Preliminary observations on a procedure resulting in fecal "continence" in five ileostomy patients.
Kock · 1969 · Arch Surg
+0.589
474 cites
8Laparoscopic total proctocolectomy with creation of ileostomy for ulcerative colitis: report of two cases.
Peters · 1992 · J Laparoendosc Surg
+0.496
63 cites
9Ulcerative colitis treated by total colectomy and ileorectal anastomosis: a ten-year review.
AYLETT · 1963 · Proc R Soc Med
+0.424
39 cites
10Proctocolectomy without ileostomy for ulcerative colitis.
Parks A · 1978 · Br Med J
+0.400
1,028 cites
11Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis
Burke · 2020 · N Engl J Med
+0.371
60 cites
12Ulcerative colitis with relative sparing of the rectum. Clinical features, histology, and prognosis.
Spiliadis · 1987 · Dis Colon Rectum
+0.356
48 cites
13Ileostomy for ulcerative colitis; technique, complications, and management.
WARREN · 1951 · Surg Gynecol Obstet
+0.314
136 cites
14Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease.
Hellers · 1980 · Gut
+0.292
364 cites
15Surgical treatment of ulcerative colitis.
CATTELL · 1948 · JAMA
+0.283
33 cites
16Life expectancy after colectomy and ileorectal anastomosis for familial adenomatous polyposis.
Nugent · 1993 · Dis Colon Rectum
+0.270
148 cites
17Extended use of sodium tetradecyl sulfate in treatment of hemangiomas and other related conditions
Woods · 1987 · Plast Reconstr Surg
+0.226
39 cites
18An Update on the Medical Management of Inflammatory Pouch Complications
Quinn · 2020 · Am J Gastroenterol
+0.221
30 cites
19Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy.
Blackstone · 1981 · Gastroenterology
+0.207
413 cites
20The relative significance of preoperative oral antibiotics, mechanical bowel preparation, and preoperative peritoneal contamination in the avoidance of sepsis after radical surgery for ulcerative colitis and Crohn's disease of the large bowel.
Barker · 1971 · Br J Surg
+0.205
57 cites
21Primary resection of the colon in acute ulcerative colitis.
RIPSTEIN · 1953 · JAMA
+0.188
21 cites
22Treatment of colorectal and ileoanal anastomotic sinuses
Whitlow · 1997 · Dis Colon Rectum
+0.166
55 cites
23Comparison of handsewn with stapled loop ileostomy closures
Hull · 1996 · Dis Colon Rectum
+0.161
58 cites
24Hyperalimentation as primary therapy for inflammatory bowel disease.
Fischer · 1973 · Am J Surg
+0.154
153 cites
25Repair of persistent perineal sinuses by means of a pedicle flap of musculus gracilis. Case report.
Bartholdson · 1975 · Scand J Plast Reconstr Surg
+0.135
41 cites
26Toxic megacolon.
1973 · Dis Colon Rectum
+0.135
20 cites
27Pouch advancement and neoileoanal anastomosis for anastomotic stricture and anovaginal fistula complicating restorative proctocolectomy
Fazio · 1992 · Br J Surg
+0.134
60 cites
28Surgical measures as supplements to the management of idiopathic ulcerative colitis; cancer, cirrhosis, and arthritis as frequent complications.
DENNIS · 1952 · Surgery
+0.133
84 cites
29The treatment of acute toxic ulcerative colitis by ileostomy and simultaneous colectomy.
CRILE · 1951 · Gastroenterology
+0.130
50 cites
30Ileorectal anastomosis: review 1952-1968.
Aylett · 1971 · Proc R Soc Med
+0.126
39 cites
31Quality of life after prophylactic colectomy and ileorectal anastomosis in patients with familial adenomatous polyposis
Church · 1996 · Dis Colon Rectum
+0.124
53 cites
32Fate of the rectal mucosa after rectal mucosectomy and ileoanal anastomosis.
Heppell · 1983 · Dis Colon Rectum
+0.121
105 cites
33Portal bacteraemia in cases of ulcerative colitis submitted to colectomy.
Eade · 1969 · Lancet
+0.118
90 cites
34An innovative technique for colorectal specimen retrieval: a new era of "natural orifice specimen extraction" (N.O.S.E)
Palanivelu · 2008 · Dis Colon Rectum
+0.117
113 cites
35Choice of operation for the toxic megacolon phase of nonspecific ulcerative colitis.
Turnbull · 1970 · Surg Clin North Am
+0.106
42 cites
36Mortality in patients with familial adenomatous polyposis.
Arvanitis · 1990 · Dis Colon Rectum
+0.105
325 cites
37The fate of ileorectal anastomosis in Crohn's disease.
Burman · 1971 · Gut
+0.104
57 cites
38Subtotal colectomy for ulcerative colitis: complications related to the rectal remnant.
Carter F · 1991 · Dis Colon Rectum
+0.101
75 cites
39Influence on sexual function of abdominoperineal resection for ulcerative colitis.
STAHLGREN · 1958 · N Engl J Med
+0.100
40 cites
40Social prognosis in patients with ulcerative colitis.
Hendriksen · 1980 · Br Med J
+0.097
51 cites
41Single-patient randomised clinical trial. Use in determining optimum treatment for patient with inflammation of Kock continent ileostomy reservoir
McLeod · 1986 · Lancet
+0.093
68 cites
42Primary closure of perineal wound after proctocolectomy or rectal excision.
Hultén · 1971 · Acta Chir Scand
+0.093
36 cites
43Laparoscopically assisted ileocolectomy in Crohn's disease.
Milsom · 1993 · Surg Laparosc Endosc
+0.091
77 cites
44Preliminary experience with laparoscopic intestinal surgery for Crohn's disease.
Ludwig · 1996 · Am J Surg
+0.084
99 cites
45Inflammatory bowel disease.
Hyams Jeffrey · 2005 · Pediatr Rev
+0.084
26 cites
46Paradoxical puborectalis contraction in patients after pelvic pouch construction
Hull · 1995 · Dis Colon Rectum
+0.080
27 cites
47Laparoscopic surgery for inflammatory bowel disease
Liu · 1995 · Am Surg
+0.078
45 cites
48Pregnancy in the patient with ileostomy and colectomy.
PRIEST · 1959 · JAMA
+0.077
22 cites
49Results of the surgical treatment of ulcerative colitis.
MILLER · 1952 · Ann Surg
+0.075
34 cites
50Operative technique in surgery for Crohn's disease and its relationship to recurrence.
Colcock · 1973 · Surg Clin North Am
+0.074
25 cites
51Unexplained bronchopulmonary disease with inflammatory bowel disease.
Kraft · 1976 · Arch Intern Med
+0.073
202 cites
52Pregnancy after ileostomy for chronic ulcerative colitis.
SCUDAMORE · 1957 · Gastroenterology
+0.072
22 cites
53Ulcerative colitis: surgical problems in corticosteroid treated patients.
PROHASKA · 1961 · Ann Surg
+0.072
23 cites
54Results of surgery for inflammatory bowel disease: a further survey of one hospital region.
Ritchie · 1974 · Br Med J
+0.069
53 cites
55Regression of rectal adenomas after colectomy and ileorectal anastomosis for familial adenomatous polyposis.
Nicholls · 1988 · Br Med J (Clin Res Ed)
+0.069
43 cites
56Effect of neostigmine on integrity of ileorectal anastomoses.
Bell · 1968 · Br Med J
+0.066
57 cites
57The role of laparoscopic surgery in the management of children and adolescents with inflammatory bowel disease.
Page · 2015 · Medicine (Baltimore)
+0.064
66 cites
58The fate of the rectal stump after subtotal colectomy for ulcerative colitis.
Oakley · 1985 · Dis Colon Rectum
+0.062
47 cites
59Clinical outcome and bowel function following total abdominal colectomy and ileorectal anastomosis in the Oriental population.
Eu · 1998 · Dis Colon Rectum
+0.060
35 cites
60Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum.
Rutgeerts · 1991 · Lancet
+0.060
598 cites
61Clinical outcome of ulcerative colitis in children.
Hyams · 1996 · J Pediatr
+0.058
127 cites
62An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir
Moskowitz · 1986 · Int J Colorectal Dis
+0.058
300 cites
63Safety of the temporary loop ileostomy
Hallböök · 2002 · Colorectal Dis
+0.056
62 cites
64PLACE OF A DOUBLE-BARRELLED ILEOSTOMY IN ULCERATIVE COLITIS AND CROHN'S DISEASE OF THE COLON: A PRELIMINARY REPORT.
TRUELOVE · 1965 · Br Med J
+0.056
66 cites
65Conservative surgery in the treatment of ulcerative colitis.
AYLETT · 1953 · Br Med J
+0.056
26 cites
66Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
Ng · 2017 · Lancet
+0.056
4,781 cites
67Adenocarcinoma of the ileostomy occurring after colectomy for ulcerative colitis: report of a case.
Sigler · 1969 · Dis Colon Rectum
+0.055
58 cites
68Endosonographic differentiation of mucosal and transmural nonspecific inflammatory bowel disease
Hildebrandt · 1992 · Endoscopy
+0.054
36 cites
69Prospective study of the effect of resection of the rectum on male sexual function
Fazio · 1980 · World J Surg
+0.052
77 cites
70Non-specific ulcerative colitis, with reference to mortality, morbidity, complications and long-term survivals following colectomy.
BACON · 1956 · Am J Surg
+0.052
24 cites
71Fluorescence angiography during transanal trans-stomal proctectomy and ileal pouch anal anastomosis: a video vignette
Spinelli · 2017 · Colorectal Dis
+0.051
21 cites
72Totally laparoscopic low anterior resection with transperineal handsewn colonic J-pouch anal anastomosis for low rectal cancer.
Person · 2006 · Surg Endosc
+0.051
28 cites
73Laparoscopic total abdominal colectomy. A prospective trial
Wexner · 1992 · Dis Colon Rectum
+0.050
191 cites
74Let sleeping dogs lie: role of the omentum in the ileal pouch-anal anastomosis procedure
Ambroze · 1991 · Dis Colon Rectum
+0.050
40 cites
75Rehabilitation and long-term survival after colectomy for ulcerative colitis.
BACON · 1960 · J Am Med Assoc
+0.050
23 cites
76Syndrome of duodenal compression by the superior mesenteric artery following restorative proctocolectomy: a case report and review of literature
Matheus Cde · 2005 · Sao Paulo Med J
+0.049
22 cites
77Sexual function in women after proctocolectomy
Metcalf · 1986 · Ann Surg
+0.049
82 cites
78A surgical subspecialist enhances general surgical operative experience
Galandiuk · 1995 · Arch Surg
+0.049
25 cites
79Ileal pouch-anal anastomosis without temporary, diverting ileostomy
Metcalf · 1986 · Dis Colon Rectum
+0.047
54 cites
80Mucosal morphology, bacteriology, and absorption in intra-abdominal ileostomy reservoir.
Philipson · 1975 · Scand J Gastroenterol
+0.047
82 cites
81Long term prognosis in ulcerative colitis--based on results from a regional patient group from the county of Copenhagen.
Hendriksen · 1985 · Gut
+0.047
219 cites
82Portal hypertension and bleeding ileal varices after colectomy and ileostomy for chronic ulcerative colitis.
Cameron · 1970 · Gut
+0.046
49 cites
83Ulcerative colitis and colorectal cancer. A population-based study.
Ekbom · 1990 · N Engl J Med
+0.046
1,440 cites
84Spleen size in patients with inflammatory bowel disease. Does it have any clinical significance?
Pereira · 1987 · Dis Colon Rectum
+0.044
35 cites
85Results of the pelvic-pouch procedure in patients with Crohn's disease.
Deutsch A · 1991 · Dis Colon Rectum
+0.044
132 cites
86Laparoscopic total abdominal colectomy with ileorectal anastomosis for familial adenomatous polyposis.
Milsom · 1997 · Dis Colon Rectum
+0.043
53 cites
87Early complications following surgical treatment for Crohn's disease.
Heimann · 1985 · Ann Surg
+0.042
77 cites
88Effects of abdominoperineal resection on sexual function in sixty patients with ulcerative colitis.
STAHLGREN · 1959 · AMA Arch Surg
+0.041
22 cites
89Long-term complications and prognosis following major surgery for ulcerative colitis.
Watts · 1966 · Br J Surg
+0.041
181 cites
90Development and Validation of Risk Matrices Concerning Ulcerative Colitis Outcomes-Bayesian Network Analysis.
Magro · 2019 · J Crohns Colitis
+0.041
20 cites
91Probiotics, immunomodulation, and health benefits
Gill · 2008 · Adv Exp Med Biol
+0.039
123 cites
92Antibiotics for inflammatory bowel disease: do they work?
Guslandi · 2005 · Eur J Gastroenterol Hepatol
+0.039
37 cites
93Diffuse ulcerative colitis and its treatment by ileo-rectal anastomosis.
AYLETT · 1960 · Ann R Coll Surg Engl
+0.038
22 cites
94Overlap in the spectrum of non-specific inflammatory bowel disease--'colitis indeterminate'.
Price · 1978 · J Clin Pathol
+0.037
264 cites
95A novel operative technique on proximal gastrectomy reconstructed by interposition of a jejunal J pouch with preservation of the vagal nerve and lower esophageal sphincter.
Tomita · 2001 · Hepatogastroenterology
+0.037
24 cites
96Prognosis after surgery for colonic Crohn's disease.
Andrews H · 1989 · Br J Surg
+0.036
54 cites
97Spontaneous resolution of rectal polyps in patients with familial polyposis following abdominal colectomy and ileorectal anastomosis.
Feinberg · 1988 · Dis Colon Rectum
+0.036
60 cites
98Review article: short chain fatty acids in health and disease
Cook · 1998 · Aliment Pharmacol Ther
+0.034
400 cites
99Self-reported food intolerance in chronic inflammatory bowel disease.
Ballegaard · 1997 · Scand J Gastroenterol
+0.033
70 cites
100Relationship of backwash ileitis to ileal pouchitis after ileal pouch-anal anastomosis
Gustavsson · 1987 · Dis Colon Rectum
+0.033
71 cites